Ucwaningo lwakamuva luphakamisa lokho Amakati aba nokuwohloka komqondo ngendlela efanayo Isifo i-Alzheimer's kubantu. Ebuchosheni bezilwane ezibonise ukudideka, izinguquko zokulala, kanye nokushintshashintsha kaningi ekuphileni, ososayensi bakhombe izimpawu ezihambisanayo ze-neuropathological ngokukhubazeka kwengqondo.
Umsebenzi, oholwa yiNyuvesi yase-Edinburgh futhi washicilelwa ku I-European Journal ye-Neuroscience, chaza ukuqoqwa kwe-beta-amyloid ekuxhumekeni kwe-neuronal kanye nezinguquko zokuvuvukala kumaseli asekela ubuchopho. Ngokusho kwethimba, le datha qinisa amakati njengesibonelo semvelo ukucwaninga ngemithi yokwelapha engazuzisa izilwane nabantu.
Okuvezwa ucwaningo
Ababhali bahlola, ngemva kokufa, ubuchopho bamakati angama-25 anomlando we-cognitive dysfunction syndrome kanye nezimpawu ezinjengokuphazamiseka kwengqondo noma ukuphazamiseka kokulala. Le ndlela yavumela ukuthi izicubu zifundwe ngokuningiliziwe futhi zihlobanisa izimpawu nokutholwe nge-microscopic.
Kusetshenziswa amasu athuthukile e-microscope, atholwe idiphozi ye-beta-amyloid kuma-synapses, amaphuzu lapho ama-neurons axhumana khona. Ukubandakanyeka kwe-Synaptic kuxhunywe ku inkumbulo nokucabanga kuyaphela Ku-Alzheimer's yomuntu, ukufana okuphindaphindiwe ezinsikazini kuyahlaziywa.
Ngaphezu kwalokho, bakubona lokho I-Astrocyte kanye ne-microglia "engulfed" ama-synapses awonakele, eyaziwa ngokuthi ukuthenwa kwe-synaptic. Le nqubo, ewusizo ekuthuthukisweni, ingaba yingozi ekugugeni kanye sheshisa ukulahleka kokuxhumana kwe-neural okuhambisana nokukhubazeka kwengqondo.
Uma kuqhathaniswa namamodeli endabuko anamagundane aguquliwe, angahlushwa ukuwohloka komqondo ngokuzenzekelayo, Amakati abonisa izinguquko zemvelo ziqhathaniswa nezabantu. Kubacwaningi, lokhu inikeza imodeli ethembeke kakhudlwana isifo elabhorethri ye-transgenic.
Izimpawu nezimpawu okufanele uziqaphele kumakati amadala
Lokhu okubizwa ngokuthi yi-cognitive dysfunction syndrome kungase kungabonakali ngoba izimpawu zayo ziqhubekela phambili kancane kancanePhakathi kwezinto ezivame kakhulu ukudideka, imijikelezo yokulala eshintshile, iphimbo lasebusuku, izinguquko ezinkambisweni, ukusetshenziswa okungafanele kwebhokisi likadoti kanye ukunganaki ekuzilungiseni noma kuntshisekelo yomdlalo.
Njengoba lezi zimpawu zingagcini nje ngokuwohloka komqondo, ukuhlolwa okuphelele kwezilwane kuyasiza khipha izinkinga ezilaphekayo njenge-hyperthyroidism, umfutho wegazi ophakeme, ukwehluleka kwezinso, i-osteoarthritis, ukulahlekelwa izinzwa noma isimila sobuchophoUkuxilongwa okuhlukile kuyisihluthulelo sokuqondisa ukuphathwa.
Ngokwethebula, uhlelo lokufunda lungabandakanya ukuhlolwa kwegazi, ukukala umfutho wegazi, ukuhlolwa kwezinzwa, nokuhlolwa kokuziphatha. Lokhu kunquma ukuthi izimpawu ziyahambisana yini ukukhubazeka kwengqondo ye-feline noma enye i-pathology.
Imithelela yocwaningo kanye nokwelashwa okungenzeka
Ucwaningo, luxhaswe ngu Wellcome kanye ne-UK Dementia Research Institute, yahlanganisa ochwepheshe base-Edinburgh, eCalifornia naseScottish Brain Sciences. Le ndlela yokubambisana ivumela ukuxhuma udokotela wezilwane kanye neurology yomuntu ukusheshisa inqubekelaphambili.
Ngokuqinisekisa ukuthi i- ukulahleka kwe-synaptic kanye ne-neuroinflammation kuhambisana nomthwalo we-amyloid, izindlela zokwelapha ziyavulwa: ukuvikela ukuxhumana kwe-neuronal, lungisa impendulo ye-glial noma uhlole izidakamizwa eziqondise i-amyloid endaweni eyenzeka ngokwemvelo ezinhlotsheni ze-feline.
Ababhali bayakhumbula ukuthi, nakuba alikho ikhambi Nge-Alzheimer's, ukuhlonza okuhlosiwe okujwayelekile kungase ngcono ukulawula izimpawu futhi uqondise izindlela zokwelapha ezisebenza ngempumelelo kokubili abantu abadala kanye nezilwane ezifuywayo.
Lokho abanakekeli abangakwenza
Ekhaya, kuhle ukunakekela izinqubo ezinzile nezibikezelwayo (ukudla, ukudlala, ukuphumula) futhi ugweme izinguquko kungazelelwe endaweni. Ukuvumelana kwansuku zonke kuzonciphisa ukukhathazeka futhi kuzokwenza kube lula ukujwayela ikati elikhulu.
Ukulungisa ikhaya kuyasiza: ukubeka amarampu noma izinyathelo, amathreyi kadoti afinyeleleka kalula, amanzi nokudla esandleni, nezibani zasebusuku ukuze ukunciphisa ukuphazamiseka phakathi nobusuku
Ukukhuthazwa kwengqondo nakho kuyanezela imidlalo yokusebenzisana, izifunzi zendida, nomsebenzi omnene ohambisana nesimo sabo. Lezi zinyathelo zinomthelela gcina ubuchopho busebenza kanye nenhlalakahle jikelele.
Nodokotela wakho wezilwane, xoxani ngohlelo olulodwa oluhlanganisa: ukudla okunama-antioxidants, ukulawula ubuhlungu noma ukukhathazeka lapho kufanele khona, nokuhlolwa njalo ukuze lungisa ukuphatha njengoba isilwane siguquka.
Ukutholwa kusenesikhathi kusiza amakati amaningi ane-cognitive dysfunction syndrome ajabulele izinga elihle lempilo iminyaka. Qaphela izimpawu zokuqala futhi ufune usizo lochwepheshe. Maka umehluko osukwini lwabo nosuku.
Lo msebenzi uyakuqinisekisa lokho Izinsikazi ezinkulu zabelana ngezindlela zobuchopho nge-Alzheimer's yomuntu: i-amyloid kuma-synapses kanye ne-pathological glial pruning. Inyunyana yomtholampilo, ilabhorethri kanye nokunakekelwa inikeza indlela ethembisayo ukuqonda nokulawula ukuwohloka komqondo kuzo zombili izinhlobo.